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Updated: Oct 1, 2026

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
Published on: October 13, 2018
Precocious puberty in a female with Proteus Syndrome
Kamal M Ezzeldin1, Asmaa A Ezzeldin, Ahmad J Zahrani
1Department of Radiology, Alnoor Specialist Hospital, Makkah, Kingdom of Saudi Arabia. kamalezzeldin@hot mail.com
Abstract:
Proteus syndrome is a complex disorder comprising malformations and overgrowth of multiple tissues and characterized by its polymorphism and mosaicism. The syndrome is rare and sporadic. Oliveira M da C et al reported the first case of Proteus syndrome associated with precocious puberty in a boy. We are reporting a case of a 7-month old girl with Proteus syndrome who developed a juvenile granulosa cell tumor in one ovary causing precocious puberty. At our knowledge this is the first case of Proteus syndrome with precocious puberty in a female.
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