[Study on anticardiolipin antibody in the patients with primary nephrotic syndrome]

Combination of the anticardiolipin antibody with the phospholipids on the surfaces of the endothelia and thrombocytes can damage the basic functions of cells. In this study, the anticardiolipin antibody was detected in 68 cases with primary nephrotic syndrome and 30 healthy persons. The positive rates were 32.35% and 3.33%, respectively. The hypercoagulability and glomerular impairment in the positive cases were more evident than those in the negative cases. In addition, the sensitivity to treatment in the positive cases was markedly decreased. These findings indicate that the anticardiolipin antibody may play an important role in pathophysiological processes of primary nephrotic syndrome.