[Effect of dimethoate on the expression of c-fos gene in skeletal muscle]
1Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing 100050, China.
Wei Sheng Yan Jiu = Journal of Hygiene Research
|April 10, 2002
Abstract:
To elucidate the effect of organophosphate pesticides on the expression of immediate early gene in skeletal muscle, the concentrations of c-fos mRNA and protein were measured by RT-PCR and western dot blot techniques. The result showed that c-fos mRNA and protein were significantly increased in skeletal muscle of rat after dosing with dimethoate. These results indicated that c-fos might act as transcription factor and regulate other gene expression during the early period of organophosphate intoxication.
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