Related Experiment Videos
Can't lung cancer patients detoxify procarcinogens?
K Cerrahoglu1, E Kunter, T Isitmangil
1GATA Camlica Chest Diseases Hospital, Department of Respiratory Diseases, Istanbul, Turkey.
Background:
Glutathione S-transferase mu (GST mu) enzyme detoxifies carcinogens in tobacco smoke. We assessed the clinical usefulness of serum assay of GSTm in determining the risk for lung cancer.
Materials And Methods:
Fifty-nine patients with primary lung cancer and 32 control cases were enrolled. GSTm detection was performed by the method ELISA.
Results:
GSTm enzyme positivity rate of the patient group (39%) was significantly lower than the control group (59.4%) (p < 0.05). The GSTm positivity rates were 28.6% for the non-smoker patients with a cancer history of relatives, 31.6% for the smoker patients with the cancer history of relatives, 14.6% for the non-smoker patients with the lung cancer history of relatives and 16.7% for the smoker patients with the lung cancer history of relatives.
Conclusions:
We concluded that if the people lacking GSTm are smokers and have a cancer and/or lung cancer history among their relatives, they would challenge a greater risk of lung cancer than the individuals having GST mu isoenzyme.
Related Concept Videos
Cancer Prevention
Some...
Mutagenicity and Carcinogenicity
Enhanced Elimination of Poison
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Other Pulmonary Disorders
Drug Elimination: Non-Renal Routes
Prevention of Further Absorption of Poison