Related Experiment Videos
High clinical inflammatory activity prior to the development of secondary progression: a prospective 5-year follow-up
B Casanova1, F Coret, C Valero
1Neurology Services of the University Hospital La Fe, Valencia, Spain. bcasanovae@meditex.es
Multiple Sclerosis (Houndmills, Basingstoke, England)
|April 10, 2002
Abstract
Objective:
To study if there are different patterns of clinical activity--measured by the annual exacerbation rate (AER)--among relapsing-remitting multiple sderosis (RRMS), "early" secondary multiple sclerosis (SPMS) and "late" SPMS.
Methods:
A prospective 5-year follow-up study in 80 MS patients has been carried out, calculating the AER and the mean expanded disability status scale (EDSS) change rate (MCR).
Results:
A significant difference on the AER, among RRMS, early SPMS and late SPMS, has been found.
Conclusions:
The SPMS has a high clinical inflammatory activity before and during its transformation from a RRMS.
