Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developments in ion mobility spectrometry-mass spectrometry.

D C Collins1, M L Lee

  • 1Weber State University, Department of Criminal Justice, Ogden, Utah 84408-1206, USA.

Analytical and Bioanalytical Chemistry
|April 10, 2002
PubMed
Summary

Ion mobility spectrometry (IMS) provides sensitive detection of organic compounds. This review highlights IMS coupled with mass spectrometry for analyzing biomolecules, explosives, and drugs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring the prognostic impact of absolute lymphocyte count in patients treated with immune-checkpoint inhibitors.

BJC reports·2024
Same author

Immune Checkpoint Inhibitors and Palliative Care at the End of Life: An Irish Multicentre Retrospective Study.

Journal of palliative care·2022
Same author

Exploiting somatic alterations as therapeutic targets in advanced and metastatic cervical cancer.

Cancer treatment reviews·2021
Same author

The interrelationship between sex skin swelling and the urinary excretion of LH, estrone, and pregnanediol by the cycling female chimpanzee.

American journal of primatology·2020
Same author

Brief Report: Differential oxidations of estradiol-17β by the chimpanzee in vivo.

American journal of primatology·2020
Same author

The impact of outpatient systemic anti-cancer treatment on patient costs and work practices.

Irish journal of medical science·2016

Area of Science:

  • Analytical Chemistry
  • Spectrometry

Background:

  • Ion mobility spectrometry (IMS) has been a sensitive technique for organic compound detection for over 30 years.
  • IMS separates ions based on their size, shape, and charge through collisions with neutral gas molecules.

Purpose of the Study:

  • To provide a review of Ion Mobility Spectrometry (IMS) principles.
  • To emphasize the applications of IMS when coupled with mass spectrometry (MS).

Main Methods:

  • Review of existing literature on IMS and its coupling with various mass spectrometry techniques.
  • Discussion of the interfacing of IMS with quadrupole, time-of-flight (TOF), and Fourier-transform ion cyclotron resonance (FTICR) mass spectrometers.

Main Results:

  • IMS-MS hybrid instruments enable the analysis of diverse analytes.
  • Successful applications include the detection of biomolecules, explosives, chemical warfare degradation products, and illicit drugs.

Conclusions:

  • The coupling of IMS with MS significantly enhances analytical capabilities.
  • IMS-MS is a versatile and powerful tool for the identification and quantification of various chemical substances.

Related Experiment Videos