Changes of biochemical bone markers during the menopausal transition

Hilkea Rosenbrock¹, Vanadin Seifert-Klauss, Susanne Kaspar

¹Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar der Technischen Universität München, Germany.

Clinical Chemistry and Laboratory Medicine

|April 10, 2002

Summary

Perimenopause accelerates bone loss, with significant increases in bone resorption markers like CTX and NTX, and bone formation markers like bone ALP and OC. These changes correlate with decreased bone mineral density, highlighting perimenopause as a critical phase for osteoporosis development.

Area of Science:

Endocrinology and Bone Metabolism
Menopause Research
Biochemistry

Background:

Bone metabolism undergoes significant changes during the menopausal transition.
Understanding these changes is crucial for early detection and prevention of osteoporosis.

Purpose of the Study:

To investigate changes in bone formation and resorption markers during the menopausal transition.
To correlate these biochemical markers with bone mineral density changes.

Main Methods:

Prospective study tracking bone markers (osteocalcin, bone ALP, BSP, PYD, DPD, CTX, NTX, TRACP) over two years.
Inclusion of healthy premenopausal, perimenopausal, and early postmenopausal women.
Statistical analysis of marker changes and correlations with bone mineral density.

Main Results:

Significant increases in resorption markers (CTX, NTX, TRACP) and formation markers (bone ALP, OC) observed during the peri- to postmenopausal transition.
Pyridinium crosslinks (PYD, DPD) indicated increased collagen degradation in perimenopause.
Inverse correlations between bone markers (bone ALP, CTX, OC, DPD) and bone mineral density changes were found in perimenopausal women.

Conclusions:

Bone metabolic changes are pronounced during perimenopause, even with adequate estrogen levels.
Perimenopause is a critical period for potential osteoporosis development.
Comprehensive biochemical marker analysis reveals significant bone turnover alterations during this transition.

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Changes of biochemical bone markers during the menopausal transition

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Changes of biochemical bone markers during the menopausal transition

Area of Science:

Background:

Purpose of the Study:

Main Methods:

Main Results:

Conclusions:

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