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Related Experiment Videos

Citalopram-induced priapism.

Larry A Dent1, Waylon C Brown, Jenny D Murney

  • 1Department of Pharmacy Practice, School of Pharmacy and Allied Health Sciences, University of Montana, Missoula 59812, USA.

Pharmacotherapy
|April 10, 2002
PubMed
Summary
This summary is machine-generated.

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Citalopram overdose can cause priapism, a prolonged erection. Patients with a history of priapism or taking alpha1-blockers like tamsulosin should be monitored closely.

Area of Science:

  • Pharmacology
  • Urology

Background:

  • Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed for depression.
  • SSRIs can cause sexual dysfunction, but serious adverse events like priapism are rare.

Observation:

  • A 58-year-old male patient inadvertently took an overdose of citalopram (60 mg total), mistaking it for aspirin.
  • He developed priapism several hours after the overdose.
  • The patient was also taking tamsulosin for benign prostatic hyperplasia and had a prior history of priapism with trazodone.

Findings:

  • Citalopram overdose was the likely cause of priapism.
  • Tamsulosin, an alpha1-blocker, may have contributed to the event.
  • The patient required intracavernous phenylephrine and surgical intervention.

Related Experiment Videos

Implications:

  • Healthcare providers should monitor patients on high-dose citalopram or those with risk factors for priapism.
  • Caution is advised when prescribing citalopram to patients with a history of priapism or those taking medications associated with priapism, such as alpha1-blockers.