Related Experiment Video
Updated: Aug 2, 2026

Photothrombosis-induced Focal Ischemia as a Model of Spinal Cord Injury in Mice
Published on: July 16, 2015
Post-epidural analgesia spinal cord infarction: MRI correlation
L L Chan1, A J Kumar, N E Leeds
1Department of Diagnostic Radiology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA. gdrcll@sgh.com.sg
Abstract:
Permanent neurological deficits after epidural analgesia are rare, but have long been believed to be caused by cord ischaemia when no obvious cause is demonstrable. The mechanisms of this injury are uncertain, but a literature review suggests important risk factors. We report a first case of extensive spinal cord infarction confirmed by magnetic resonance imaging (MRI) following post-thoracotomy epidural analgesia and review the literature to explain the mechanism underlying this devastating complication.
Insights
Permanent neurological deficits from epidural analgesia are rare but can cause spinal cord infarction. This case highlights potential mechanisms and risk factors for this devastating complication.
Area of Science:
- Neurology
- Anesthesiology
- Radiology
Background:
- Permanent neurological deficits after epidural analgesia are rare.
- Cord ischemia is the suspected cause when no other cause is evident.
- Mechanisms of this neurological injury remain uncertain.
Observation:
- This study reports a rare case of extensive spinal cord infarction.
- The infarction was confirmed by magnetic resonance imaging (MRI).
- The complication occurred following post-thoracotomy epidural analgesia.
Findings:
- The case provides evidence of spinal cord infarction as a cause of neurological deficits after epidural analgesia.
- Literature review suggests significant risk factors associated with this complication.
- The study aims to elucidate the underlying mechanisms of this adverse event.
Implications:
- Understanding the mechanisms of spinal cord infarction is crucial for preventing neurological deficits.
- Identifying risk factors can help clinicians optimize patient safety during epidural analgesia.
- This research contributes to the knowledge of rare but severe complications associated with epidural procedures.
![Autoradiographic Measurements of [14C]-Iodoantipyrine in Rat Brain Following Central Post-Stroke Pain](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F53947.jpg&w=3840&q=50)
