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Updated: Jul 22, 2026
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Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation
Published on: October 2, 2015
Second-generation microstimulator
1Alfred E. Mann Foundation, Valencia, California 91355, USA. isabela@aemf.org
Artificial Organs
|April 10, 2002
Summary
The new BION microstimulator, a ceramic-encased device, shows safe and effective long-term implantation in rats. This injectable device is suitable for wireless stimulating systems and potential human use.
Area of Science:
- Biomedical Engineering
- Materials Science
- Neuroscience
Background:
- First-generation microstimulators were glass-encased.
- Second-generation BION devices feature hermetically sealed ceramic cases with platinum electrodes for enhanced durability.
- Zener diodes offer protection against defibrillation and electrostatic discharge.
Purpose of the Study:
- To evaluate the safety and efficacy of the second-generation BION microstimulator for long-term implantation.
- To assess tissue response and stimulation threshold stability over time.
- To validate the BION as a component for wireless stimulating systems.
Main Methods:
- Implantation of BION devices in rats for up to 5 months.
- Histological analysis to assess tissue encapsulation.
- Monitoring of stimulation threshold levels over the implantation period.
Main Results:
- Benign tissue reactions observed, with encapsulation comparable to controls.
- No significant changes in stimulation threshold levels over time (0.81–1.35 mA).
- Successful integration within a 255-channel wireless stimulating system.
Conclusions:
- The second-generation BION microstimulator demonstrates safety and efficacy for long-term implantation.
- The device is suitable for use in wireless stimulating systems.
- Collaboration is sought for further BION application development.
