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Related Experiment Videos

Second-generation microstimulator.

Isabel Arcos1, R Davis, K Fey

  • 1Alfred E. Mann Foundation, Valencia, California 91355, USA. isabela@aemf.org

Artificial Organs
|April 10, 2002
PubMed
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The new BION microstimulator, a ceramic-encased device, shows safe and effective long-term implantation in rats. This injectable device is suitable for wireless stimulating systems and potential human use.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Neuroscience

Background:

  • First-generation microstimulators were glass-encased.
  • Second-generation BION devices feature hermetically sealed ceramic cases with platinum electrodes for enhanced durability.
  • Zener diodes offer protection against defibrillation and electrostatic discharge.

Purpose of the Study:

  • To evaluate the safety and efficacy of the second-generation BION microstimulator for long-term implantation.
  • To assess tissue response and stimulation threshold stability over time.
  • To validate the BION as a component for wireless stimulating systems.

Main Methods:

  • Implantation of BION devices in rats for up to 5 months.
  • Histological analysis to assess tissue encapsulation.

Related Experiment Videos

  • Monitoring of stimulation threshold levels over the implantation period.

    • Main Results:

    • Benign tissue reactions observed, with encapsulation comparable to controls.
    • No significant changes in stimulation threshold levels over time (0.81–1.35 mA).
    • Successful integration within a 255-channel wireless stimulating system.

    Conclusions:

    • The second-generation BION microstimulator demonstrates safety and efficacy for long-term implantation.
    • The device is suitable for use in wireless stimulating systems.
    • Collaboration is sought for further BION application development.