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NK cells, MHC class I molecules and the missing self.

¹Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden. klas.karre@mtc.ki.se

Scandinavian Journal of Immunology

|April 10, 2002

Summary

Natural killer (NK) cells identify and eliminate cells lacking normal self-markers, according to the missing-self recognition model. This research explores the model's development and surprising prediction inaccuracies.

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Area of Science:

Immunology
Cellular Biology

Background:

The missing-self recognition model proposes that natural killer (NK) cells eliminate target cells lacking normal self-markers.
This concept led to predictions of inhibitory receptors crucial for NK cell function.

Purpose of the Study:

To provide a personal and historical perspective on the development of the missing-self recognition model for NK cells.
To discuss the research journey, including hypothesis formulation, experimental testing, and collaborations during the 1980-1990 decade.

Main Methods:

Historical review of research and personal accounts.
Discussion of hypothesis formulation, experimental validation, and collaborative efforts.
Analysis of the missing-self hypothesis predictions against current knowledge.

Main Results:

The missing-self hypothesis predicted the existence of inhibitory Major Histocompatibility Complex (MHC) class I specific receptors.
Research during the 1980s established key factors in developing and advancing this model.
Some predictions of the missing-self hypothesis were found to be inaccurate or incomplete upon later review.

Conclusions:

The missing-self recognition model has been pivotal in understanding NK cell biology.
International collaboration and reagent exchange were crucial for the model's progression.
Acknowledging prediction limitations provides valuable insights for future research in NK cell immunology.

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