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Ventricular remodeling by Scutellarein treatment in spontaneously hypertensive rats
Jianzhong Zhou1, Han Lei, Yunzhen Chen
1Department of Internal Medicine, The First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016, China.
Objective:
To observe reversal of ventricular remodeling by the protein kinase C inhibitor Scutellarein in spontaneously hypertensive rats (SHRs).
Methods:
Twelve SHRs were randomly divided into two groups. Scutellarein and saline (10 mg x kg(-1) x d(-1)) were given by intraperitoneal injection to two groups of rats separately. Systolic blood pressure (SBP) and ventricular weight index (LVW/BW, RVW/BW) were measured. A polarization microscope and an image analyzer system (IAS) were used to observe changes in cardiovascular structure and to count the content of cardiac muscle interstitial collagen.
Results:
The pathologic changes in the left ventricle in the Scutellarein group rats (SHR(D)) improved to varying degrees, including hypertrophy of the cardiac muscle and collagen volume fraction.
Conclusion:
Scutellarein can reverse ventricular remodeling, improve myocardial stiffness and protect heart cardiac muscle.