Quantitative Neuropathology in Electrically Induced Generalized Convulsions

A critical review of the neuropathology associated with seizures is presented, with special reference to the damage to the brain claimed to result from electroconvulsive treatment (ECT). From the point of view of neuron loss, there is no evidence that single seizures (convulsions), even if repeated, result in this type of damage to the brain, which is the only definitely irreversible kind. Pitfalls of the methods of investigation available in neuropathology are described to support this statement. Basic differences between epileptic seizures and induced seizures are emphasized in relation to neuron loss in epilepsy.