Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

ECT: Clinical Variables, Seizure Duration, and Outcome.

Charles F. Zorumski1, William J. Burke, James L. Rutherford

  • 1Washington University School of Medicine, Department of Psychiatry, St. Louis, Missouri, USA.

Convulsive Therapy
|January 1, 1986
PubMed
Summary

Predicting electroconvulsive therapy (ECT) response is challenging. This study found that longer total seizure time, measured by electroencephalogram (EEG), correlates with better patient outcomes, supporting a minimum seizure duration threshold for effectiveness.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relationship of age of first drink to child behavioral problems and family psychopathology.

Alcoholism, clinical and experimental research·2005
Same author

Whole genome linkage scan of recurrent depressive disorder from the depression network study.

Human molecular genetics·2005
Same author

Long-term stability of alcohol and other substance dependence diagnoses and habitual smoking: an evaluation after 5 years.

Archives of general psychiatry·2005
Same author

Are there subgroups of bulimia nervosa based on comorbid psychiatric disorders?

The International journal of eating disorders·2005
Same author

The Depression Network (DeNT) Study: methodology and sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetic study.

BMC psychiatry·2004
Same author

A family study of alcohol dependence: coaggregation of multiple disorders in relatives of alcohol-dependent probands.

Archives of general psychiatry·2004

Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Neurophysiology

Background:

  • Predicting electroconvulsive therapy (ECT) response is crucial for optimizing patient care.
  • Existing models suggest seizure duration may be a key factor, but evidence is limited.

Purpose of the Study:

  • To investigate the relationship between seizure duration and treatment response in patients undergoing ECT.
  • To determine if a minimum seizure time threshold or a therapeutic window exists for ECT efficacy.

Main Methods:

  • Utilized bifrontal electroencephalogram (EEG) electrodes to measure total seizure time during ECT.
  • Correlated cumulative seizure duration with clinical treatment outcomes in a patient cohort.

Main Results:

Related Experiment Videos

  • Total seizure time demonstrated a significant correlation with treatment outcome (r(s) = 0.43, p < 0.01).
  • A substantial majority (88%) of patients with cumulative seizure times exceeding 300 seconds showed favorable responses (chi(2) = 6.80, p < 0.01).

    • Conclusions:

    • Findings support the hypothesis that a minimum accumulated seizure time is necessary for a positive clinical response to ECT.
    • No evidence was found to suggest an upper limit of benefit, refuting the existence of a 'therapeutic window' for seizure duration in this context.