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Electroconvulsive Therapy in Multiple Sclerosis: A Magnetic Resonance Imaging Study of the Brain

C. Edward Coffey1, Richard D. Weiner, W. Vaughn McCall

  • 1Departments of Psychiatry and Medicine (Neurology), Duke University Medical Center, Durham, North Carolina, USA.

Convulsive Therapy
|January 1, 1987
PubMed

A depressed woman with multiple sclerosis was successfully treated with electroconvulsive therapy without any adverse effects to her neurologic status. Magnetic resonance imaging of the brain was performed before and after the course of therapy and revealed no change in the white matter lesions visualized on spin-echo images.

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Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early years,...