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Related Experiment Videos

Serotonin and Electroconvulsive Shock-Induced Prolactin Release.

Conrad M. Swartz1, Richard Abrams, Victoria Drews

  • 1Departments of Psychiatry and Pharmacology, University of Health Sciences/The Chicago Medical School; and North Chicago Veterans Administration Medical Center, North Chicago, Illinois, USA.

Convulsive Therapy
|January 1, 1988
PubMed
Summary

Electroconvulsive shock (ECS) did not increase prolactin without ketanserin. With ketanserin, ECS still increased prolactin, suggesting serotonin does not significantly impact ECS-induced prolactin release.

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Area of Science:

  • Neuroendocrinology
  • Pharmacology

Background:

  • Serotonergic pathways modulate various physiological responses.
  • The role of serotonin in electroconvulsive shock (ECS)-induced prolactin release is not fully understood.

Purpose of the Study:

  • To investigate the involvement of serotonin-2 (5-HT(2)) receptors in ECS-induced prolactin secretion in rabbits.

Main Methods:

  • Serum prolactin levels were measured in rabbits before and after ECS.
  • Experiments were conducted both with and without pretreatment with ketanserin, a 5-HT(2) receptor blocker.

Main Results:

  • ECS did not elevate prolactin levels in rabbits without ketanserin pretreatment.
  • Ketanserin pretreatment lowered baseline prolactin and resulted in post-ECS prolactin levels twice the new baseline, similar to levels without ketanserin.

Related Experiment Videos

  • This indicates minimal contribution of serotonergic neurotransmission to ECS-induced prolactin release.

    • Conclusions:

    • Serotonergic neurotransmission potentiates stress-induced prolactin secretion.
    • Serotonin plays a limited role in ECS-induced prolactin release.