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Related Experiment Videos

Does Fluoxetine Prolong Electrically Induced Seizures?

Rolando Gutierrez-Esteinou1, Harrison G. Pope

  • 1Biological Psychiatry Laboratory, Laboratories for Psychiatric Research, Psychosis Program, McLean Hospital, Belmont, Massachusetts, and Harvard Medical School, Boston, Massachusetts, USA.

Convulsive Therapy
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

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This study found that fluoxetine, an antidepressant, does not prolong seizures in patients undergoing electroconvulsive therapy (ECT). Fluoxetine did not increase seizure duration or the risk of prolonged seizures during ECT treatment.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Psychiatry

Background:

  • The antidepressant fluoxetine is known to interact with electroconvulsive therapy (ECT).
  • Product literature suggests fluoxetine may prolong seizures during ECT.

Purpose of the Study:

  • To investigate whether fluoxetine use is associated with prolonged seizures in patients undergoing ECT.
  • To compare seizure durations and incidence of prolonged seizures between patients on fluoxetine and controls.

Main Methods:

  • A comparative study involving 12 patients receiving ECT plus fluoxetine and 25 control patients receiving ECT alone.
  • Measurement of seizure durations and incidence of prolonged seizures.

Main Results:

  • No significant difference in seizure durations or incidence of prolonged seizures was observed between the fluoxetine and control groups.

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  • Higher fluoxetine doses were associated with slightly shorter seizure durations.
  • Greater stimulus energy was required to elicit seizures in the fluoxetine group.

    • Conclusions:

    • Fluoxetine does not appear to prolong electrically induced seizures in patients undergoing ECT.
    • The findings contradict concerns raised by product literature regarding fluoxetine and ECT seizure duration.