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Related Concept Videos

What is the Immune System?01:38

What is the Immune System?

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Humoral Immune Responses01:36

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Cells of the Adaptive Immune Response01:23

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Antibody Actions01:26

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Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
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Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
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Subsequent T...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...

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Simultaneous Quantification of T-Cell Receptor Excision Circles (TRECs) and K-Deleting Recombination Excision Circles (KRECs) by Real-time PCR
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Primary immunodeficiency disorders: antibody deficiency.

Mark Ballow1

  • 1Division of Allergy/Clinical Immunology and Pediatric Rheumatology, Department of Pediatrics, Children's Hospital of Buffalo, SUNY Buffalo School of Medicine and Biomedical Sciences, Buffalo 14222, USA.

The Journal of Allergy and Clinical Immunology
|April 10, 2002
PubMed
Summary

Antibody deficiencies are common primary immune disorders. Recent molecular immunology advances improve understanding of B-cell development and pathogenesis, aiding patient management.

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Flow Cytometric Characterization of Murine B Cell Development

Published on: January 22, 2021

Area of Science:

  • Immunology
  • Genetics

Background:

  • Antibody deficiencies are the most frequent primary immune deficiencies.
  • Symptoms often manifest after maternal IgG wanes, increasing infection susceptibility.
  • Clinical presentations range from absent B cells to selective deficiencies, with associated autoimmunity and malignancies.

Purpose of the Study:

  • To review the spectrum and pathogenesis of antibody deficiencies.
  • To highlight recent advances in molecular immunology for understanding these conditions.
  • To discuss improved patient management strategies.

Main Methods:

  • Review of current literature on antibody deficiencies.
  • Analysis of molecular immunology findings.
  • Discussion of B-cell development and differentiation pathways.

Main Results:

  • Identification of genes involved in various antibody deficiencies.
  • Elucidation of B-cell development and differentiation.
  • Enhanced understanding of disease pathogenesis.

Conclusions:

  • Molecular immunology has significantly advanced the understanding of antibody deficiencies.
  • Improved knowledge aids in better patient management and treatment.
  • Further research into B-cell pathways promises continued progress.