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[Analyses of genetic model of psoriasis vulgaris]
Xuejun Zhang1, Hongyan Wang, Shanyu Chen
1Institute of Dermatology and Department of Dermatology, Anhui Medical University, Hefei, Anhui, 230022 P. R. China. ayzxj@mail.hf.ah.cn
Objective:
To explore the possible genetic model of psoriasis vulgaris.
Methods:
The complex segregation analysis and heritability calculation were performed with the aid of Penrose method, Falconer regression method and SAGE-REGTL program.
Results:
It was found that in 1043 patients with psoriasis vulgaris, 305 patients (29.24%) have the family history of psoriasis, and 738 patients have not the family history. A ratio of s/q approached 1/(square root of q) with Penrose method, and the heritability values of psoriasis in the first-degree and second-degree relatives were 67.04%, 46.6% respectively. By complex segregation analysis, Mendelian, non-major-gene model and environment model were rejected for psoriasis.
Conclusion:
The results suggest that psoriasis follows a pattern of polygenetic or multifactorial inheritance rather than single-gene inheritance.