Related Experiment Video
Updated: Aug 19, 2026
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Asthma predictors in infantile atopic dermatitis
Insights
Persistent infantile eczema continuing beyond two years is a strong predictor of childhood asthma. Eczema severity and onset timing were not significant predictors for developing asthma.
Area of Science:
- Pediatrics
- Allergy and Immunology
- Dermatology
Background:
- Childhood asthma is a significant health concern.
- Identifying early predictive factors is crucial for timely intervention.
- Atopic dermatitis (eczema) in infancy is a potential early indicator.
Purpose of the Study:
- To investigate predictive factors for childhood asthma.
- To examine the relationship between infantile atopic dermatitis and later asthma development.
Main Methods:
- A cohort of 60 children with infantile atopic dermatitis was followed.
- Children were assessed between 6-11 years of age.
- Asthma development was compared between children with persistent vs. non-persistent eczema.
Main Results:
- Continuation of atopic dermatitis beyond two years of age was highly predictive of childhood asthma.
- Eczema severity in infancy was not a strong predictor in boys and not in girls.
- Persistent eczema was more common in asthmatic boys than girls.
Conclusions:
- Persistent infantile eczema is a key predictor for childhood asthma.
- Early identification of persistent eczema can aid in asthma risk assessment.
- Further research into sex-specific differences in eczema-asthma links is warranted.
Abstract:
In a search for predictive factors in early childhood for later developing childhood asthma, sixty chidren who suffered in the first year of life from atopic dermatitis were examined at ages between 6-11 years. There were 40 boys and 20 girls, of whom 21 were asthmatic boys and 10 asthmatic girls. The non-asthma group was similar to the asthma group in age, sex and socio-economic background and familial-hereditary background. The psychosocial aspects of the study were not reported in this paper. The atopic dermatitis followed a different pattern in the asthmatic group than in the non-asthma group. A continuation of the atopic eczematous condition in infancy beyond two years appeared to be highly predictive for future childhood asthma. Severity of the eczema in infancy does not seem to be a strong predictor in boys and not at all in the small group of girls. Persistent eczema appeared twice as much in the asthmatic boys as in the asthmatic girls. There was no distinct difference between the asthmatic children and the non-asthmatic children in time of onset of the infantile eczema nor in the location of the atopic dermatitis.
More Related Videos
Related Concept Videos
01:20Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:29Asthma-I: Introduction
01:26Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
01:30Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
01:28Asthma I: Introduction
01:13Asthma III: Clinical Manifestations