Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Progressive multifocal leukoencephalopathy limited to the brain stem.

O Kastrup1, M Maschke, H C Diener

  • 1Neurologische Universitätsklinik, University of Essen, Germany. oliver.kastrup@uni-essen.de

Neuroradiology
|April 11, 2002
PubMed
Summary

Progressive multifocal leukoencephalopathy (PML) is a rare, rapidly fatal brain infection in AIDS patients. This case showed brainstem-confined lesions and rapid progression despite treatment, highlighting PML

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Placebo Response in Acute and Prophylactic Treatment of Migraine: A Systematic Review and Meta-Analysis Covering 36 Years of Research.

Neurologic clinics·2025
Same author

[Diagnosis and treatment of acute ischemic insults].

Herz·2021
Same author

European Academy of Neurology guideline on the management of medication-overuse headache.

European journal of neurology·2020
Same author

MMW Fortschritte der Medizin·2018
Same author

Preventing dementia beyond treating hypertension.

European heart journal·2018
Same author

MMW Fortschritte der Medizin·2018

Area of Science:

  • Neuroscience
  • Virology
  • Immunology

Background:

  • Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease caused by the JC polyomavirus, typically affecting immunocompromised individuals, particularly those with AIDS.
  • PML commonly presents with cerebral hemisphere lesions on MRI, but rare presentations can occur.

Observation:

  • A rare case of rapidly progressing and lethal PML in an AIDS patient with severe bulbar syndrome and spastic tetraparesis is presented.
  • Magnetic resonance imaging (MRI) revealed high-signal lesions restricted to the brainstem, from the medulla oblongata to the midbrain.

Findings:

  • JC virus polymerase chain reaction in cerebrospinal fluid was positive, confirming the diagnosis.
  • Neuropathology confirmed the findings consistent with PML.

Related Experiment Videos

  • The patient experienced rapid disease progression despite an improved immune status due to antiretroviral therapy.

    • Implications:

    • This case underscores the potential for severe, brainstem-confined PML presentations in AIDS patients.
    • The rapid progression despite antiretroviral therapy suggests potential limitations of current treatments in certain PML cases.
    • Further research into understanding and managing aggressive PML variants is warranted.