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Concurrent spinal cord and vertebral bone marrow radionecrosis 8 years after therapeutic irradiation
L Warscotte1, T Duprez, M Lonneux
1Department of Neurology, Université catholique de Louvain, Cliniques universitaires Saint-Luc, Brussels, Belgium.
Neuroradiology
|April 11, 2002
Abstract:
Concurrent radionecrosis within the spinal cord and the bone marrow at the same thoracic level was observed 8 years after localized therapeutic irradiation in a patient who had undergone repeated cycles of radiotherapy, glucocorticoid treatment, and chemotherapy for a non-Hodgkin's lymphoma. Mechanisms combining radiotoxic potentialization by glucocorticoids/alkylating agents and delayed radiation-induced vasculitis involving the common arterial pathways to the spinal cord and to the vertebrae were speculated to have acted in a synergistic way.