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Related Experiment Videos

Proton MR spectroscopic imaging in multiple sclerosis.

G Tedeschi1, S Bonavita, H F McFarland

  • 1Istituto di Scienze Neurologiche, Seconda Università di Napoli, Italy. gioacchino.tedeschi@unina2.it

Neuroradiology
|April 11, 2002
PubMed
Summary

Proton magnetic resonance spectroscopic imaging revealed neurochemical changes in multiple sclerosis (MS) white matter lesions and normal-appearing white matter. These findings indicate myelin and axonal damage, extending understanding of MS pathology beyond visible MRI abnormalities.

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Area of Science:

  • Neuroimaging
  • Neuroscience
  • Biochemistry

Background:

  • Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system.
  • Neurochemical alterations in white matter lesions (WML) and normal-appearing white matter (NAWM) are key to understanding MS pathology.
  • Magnetic Resonance Spectroscopic Imaging (MRSI) offers a non-invasive method to assess brain metabolites.

Purpose of the Study:

  • To investigate the neurochemical differences between WML, NAWM, and control white matter in MS patients using proton MRSI (1H-MRSI).
  • To evaluate the specific metabolite ratios (NAA/Cr, NAA/Cho, Cho/Cr) indicative of pathological processes.

Main Methods:

  • Utilized 1H-MRSI to simultaneously measure N-acetylaspartate (NAA), choline-containing compounds (Cho), and creatine/phosphocreatine (Cr) in 24 MS patients.

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  • Acquired data from four 15-mm slices, with 0.84 ml single-volume elements, comparing WML, NAWM, and control white matter.

    • Main Results:

    • Significantly reduced NAA/Cr and NAA/Cho ratios were observed in WML compared to NAWM and control white matter.
    • A significantly higher Cho/Cr ratio was found in WML versus NAWM and control white matter.
    • NAWM showed significantly lower NAA/Cr and Cho/Cr ratios compared to control white matter.

    Conclusions:

    • 1H-MRSI findings suggest myelin damage in WML and axonal damage/dysfunction in both WML and NAWM.
    • The study highlights the involvement of NAWM in MS, extending beyond visible MRI lesions.
    • MRSI provides valuable insights into the complex neurochemical pathology of multiple sclerosis.