Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A status-based approach to multiple strain dynamics.

J R Gog1, J Swinton

  • 1Department of Zoology, University of Cambridge, UK. julia@zoo.cam.ac.uk

Journal of Mathematical Biology
|April 11, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An in silico canine cardiac midmyocardial action potential duration model as a tool for early drug safety assessment.

American journal of physiology. Heart and circulatory physiology·2011
Same author

Moving inwards, moving outwards, moving upwards: the role of spirituality during the early stages of breast cancer.

European journal of cancer care·2011
Same author

Measuring social networks in British primary schools through scientific engagement.

Proceedings. Biological sciences·2010
Same author

Decreased internalisation of erbB1 mutants in lung cancer is linked with a mechanism conferring sensitivity to gefitinib.

Systems biology·2006
Same author

The onset of oscillatory dynamics in models of multiple disease strains.

Journal of mathematical biology·2002
Same author

Spirituality. Come all ye faithful.

The Health service journal·2002

This study introduces a novel cross-immunity model, representing hosts by their current immune status rather than infection history. This new framework reveals that a specific four-strain system does not exhibit sustained oscillations, offering insights into strain diversity maintenance.

Area of Science:

  • Immunology
  • Mathematical Biology
  • Epidemiology

Background:

  • Traditional cross-immunity models classify hosts by infection history.
  • A new host representation based on current immune response status is proposed.
  • This status-based framework broadens the study of cross-immunity forms.

Purpose of the Study:

  • To introduce and investigate a novel model for cross-immunity.
  • To analyze a specific four-strain system with partial cross-immunity.
  • To explore applications in maintaining genetic strain diversity.

Main Methods:

  • Representing hosts by their current immune response status.
  • Analyzing a four-strain system where each strain confers partial immunity to two others.
  • Utilizing system symmetries to identify a relevant invariant subspace for analysis.

Related Experiment Videos

Main Results:

  • The new framework allows for a wider and more biologically interpretable range of cross-immunity forms.
  • Substantial analytical progress was made on the four-strain system by focusing on an invariant subspace.
  • The analyzed system does not exhibit sustained oscillations for any parameter values, unlike previously studied systems.

Conclusions:

  • The status-based cross-immunity model provides a more flexible and interpretable approach.
  • The analysis of the four-strain system offers insights into the dynamics of strain diversity.
  • The absence of sustained oscillations in this model has implications for understanding pathogen evolution and control.