Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interleukin-10 in the brain.

K Strle1, J H Zhou, W H Shen

  • 1Department of Animal Sciences, College of Medicine, University of Illinois, Urbana 61801, USA.

Critical Reviews in Immunology
|April 11, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Interpretation for the health professional standards in appropriate range of body mass index and body weight management for the oldest old].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2026
Same author

[Association between urinary nickel levels and impaired kidney function in older adults aged 65 years and above in 18 longevity areas in China].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2026
Same author

[Associations of plant based dietary intake and physical activity with depression symptoms in older adults aged 65 years and above in longevity areas in China].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2026
Same author

[Association between physical activity and sarcopenia among older adults aged 65 and above in longevity areas of China].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2026
Same author

[Association between physical activity and non-alcoholic fatty liver disease among adults aged 65 and above in longevity regions of China].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2026
Same author

[Clinical effect analysis of sintilimab combined with chemotherapy in the treatment of malignant pleural mesothelioma].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2026
Same journal

Leveraging Type I Interferons: Exploring Pathogenesis and Therapeutic Strategies in Autoimmune Diseases.

Critical reviews in immunology·2026
Same journal

SLC2A1-Dependent Ketone Metabolism Regulates Tumor Progression and Immunotherapy Efficacy in Lung Adenocarcinoma.

Critical reviews in immunology·2026
Same journal

Knockdown of IGF2BP2 Inhibits THBS1 in Regulating the Progression of Oral Squamous Cell Carcinoma: An Integrative Analysis.

Critical reviews in immunology·2026
Same journal

Plasmodium Phosphatidylinositol 4-Kinase Beta (PI4Kβ): An Emerging Target at the Interface of Parasite Biology and Host Immunity.

Critical reviews in immunology·2026
Same journal

Fusion Gene EPHB4-MET Driven by HOXA9 and Exerted Oncogenic Activity in Non-Small Cell Lung Cancer.

Critical reviews in immunology·2026
Same journal

Secreted Phosphoprotein 1 Represents a Therapeutic Target that Promotes the Progression of Ovarian Cancer by Driving M2 Macrophage Infiltration.

Critical reviews in immunology·2026
See all related articles

Interleukin-10 (IL-10) in the central nervous system (CNS) limits neurological disease symptoms and promotes cell survival by blocking apoptosis and inflammation. This anti-inflammatory cytokine offers potential therapeutic strategies for neurodegenerative diseases.

Area of Science:

  • Neuroscience
  • Immunology
  • Cell Biology

Background:

  • Interleukin-10 (IL-10) is synthesized in the central nervous system (CNS).
  • IL-10 expression is elevated in major CNS diseases, including stroke, multiple sclerosis, Alzheimer's disease, and meningitis.
  • IL-10 plays a crucial role in limiting clinical symptoms and behavioral changes associated with CNS diseases and infections.

Purpose of the Study:

  • To elucidate the multifaceted roles of IL-10 in the CNS.
  • To understand how IL-10 promotes neuronal and glial cell survival.
  • To explore IL-10's mechanisms in limiting neuroinflammation and T cell activity.

Main Methods:

  • Review of IL-10's signaling pathways (Jak1/Stat3, PI 3-kinase, MAPK, SOCS, NF-kappaB).
  • Analysis of IL-10's effects on apoptotic pathways (ligand- and mitochondrial-induced).

Related Experiment Videos

  • Examination of IL-10's anti-inflammatory mechanisms and T cell modulation.

    • Main Results:

    • IL-10 promotes cell survival by inhibiting proapoptotic cytokines and enhancing survival signals.
    • IL-10 limits neuroinflammation by reducing pro-inflammatory cytokine synthesis, suppressing receptor expression, and inhibiting receptor activation.
    • IL-10 induces T cell anergy in the brain by inhibiting CD28-CD80/86 signaling.

    Conclusions:

    • IL-10 is a key neuroprotective and anti-inflammatory cytokine in the CNS.
    • Understanding IL-10's functions provides insights into neurodegenerative diseases.
    • IL-10 represents a potential therapeutic target for treating debilitating CNS disorders.