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Lignans and neolignans from Myristica argentea Warb
F Filleur1, C Pouget, D P Allais
1UPRES EA 1085: Laboratoire de Pharmacognosie et de Phytochimie, UFR de Pharmacie, Université de Limoges, France.
Natural Product Letters
|April 11, 2002
Summary
Researchers investigated the chemical constituents of Myristica argentea Warb. mace, identifying six phenylpropenes, lignans, neolignans, and a novel dilignan, bis erythro-argenteane.
Area of Science:
- Phytochemistry
- Natural Product Chemistry
- Organic Chemistry
Background:
- Myristica argentea Warb. (mace) is a spice with a rich history of traditional use.
- The chemical composition of M. argentea Warb. mace is not fully elucidated, particularly regarding its phenylpropanoid and lignan content.
Purpose of the Study:
- To isolate and identify the chemical constituents present in the petrol extract of Myristica argentea Warb. mace.
- To characterize any novel compounds discovered during the phytochemical investigation.
Main Methods:
- Extraction of mace from Myristica argentea Warb. using petrol solvent.
- Chromatographic separation techniques (e.g., column chromatography) to isolate individual compounds.
- Spectroscopic methods (e.g., NMR, MS) for structural elucidation of the isolated compounds.
Main Results:
- Six phenylpropenes were identified in the extract.
- Three lignans and three neolignans were isolated and characterized.
- A new dilignan, bis erythro-argenteane (rel-(8R,8'S,8"S,8"'R)-5',5"-bis(7-(3,4-methylenedioxyphenyl)-7'-(4'-hydroxy-3'-methoxyphenyl)-8.8'-lignane)), was discovered.
Conclusions:
- The petrol extract of Myristica argentea Warb. mace is rich in phenylpropenes, lignans, and neolignans.
- Bis erythro-argenteane represents a novel natural product with potential for further investigation.