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Candida albicans Biofilm Chip (CaBChip) for High-throughput Antifungal Drug Screening
08:05

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Antifungal drug resistance of pathogenic fungi

Dimitrios P Kontoyiannis1, Russell E Lewis

  • 1Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA. dkontoyi@mdanderson.org

Lancet (London, England)
|April 12, 2002
PubMed

Insights

Pathogenic fungi develop complex antifungal drug resistance. Understanding these resistance mechanisms is key to improving treatments for difficult fungal infections.

Area of Science:

  • Medical Mycology
  • Antimicrobial Resistance

Background:

  • Pathogenic fungi exhibit intricate mechanisms for resisting antifungal medications.
  • Growing body of research details clinical, cellular, and molecular factors in antifungal drug resistance.

Purpose of the Study:

  • To critically review the diagnosis, epidemiology, and mechanisms of antifungal drug resistance in pathogenic fungi.
  • To provide a comprehensive overview for researchers and clinicians.

Main Methods:

  • Literature review and critical analysis of existing studies on antifungal drug resistance.
  • Synthesis of information on diagnostic approaches, epidemiological trends, and molecular resistance pathways.

Main Results:

  • Detailed examination of various resistance mechanisms employed by pathogenic fungi.
  • Identification of key factors influencing the development and spread of antifungal resistance.

Conclusions:

  • Enhanced understanding of antifungal resistance is crucial for advancing diagnostic strategies.
  • Improved detection and knowledge of resistance mechanisms will aid in preventing and treating refractory fungal infections (mycoses).

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