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[Experimental study on stimulation of guided bone regeneration by autogenous bone marrow]
1Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, P. R. China 430071.
Objective:
To study the effect of autogenous bone marrow on guided bone regeneration (GBR), and evaluate the repairing ability of GBR in bone defect with autogenous bone marrow.
Methods:
Ten mm segmental defects were produced in both radii of 18 rabbits. The defect was bridged with a silicon tube. Autogenous bone marrow was injected into the tube on the experimental group at 0, 2, 4 weeks after operation, and peripheral blood into the control group at the same time. The X-ray, gross, histological and biochemical examinations were observed in various times.
Results:
The new bone formation of experimental group was prior to that of control group; calcium and alkaline phosphatase of experimental group were higher than those of control group. The experimental group had all been healed at the tenth week, but no one healed in control group.
Conclusion:
It can be conclude that autogenous bone marrow can stimulate bone formation and facilitate GBR in bone defect.