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Pulsatile ocular blood flow in patients with pseudoexfoliation
A Mistlberger1, M Gruchmann, W Hitzl
1Department of Ophthalmology, County Hospital Salzburg.
International Ophthalmology
|April 12, 2002
Summary
Pulsatile ocular blood flow (POBF) differs significantly in pseudoexfoliation glaucoma (PEG) but not in pseudoexfoliation syndrome (PEX) alone. Ocular blood flow correlates with intraocular pressure and nerve fiber layer thickness.
Area of Science:
- Ophthalmology
- Cardiovascular Physiology
- Glaucoma Research
Background:
- Pseudoexfoliation syndrome is a frequent cause of open-angle glaucoma.
- It is linked to systemic vascular conditions like hypertension and stroke.
- Evaluating ocular hemodynamics is crucial for understanding disease progression.
Purpose of the Study:
- To assess pulsatile ocular blood flow (POBF) in pseudoexfoliation syndrome (PEX) without glaucoma.
- To compare POBF in pseudoexfoliation glaucoma (PEG) with normal controls.
- To investigate correlations between POBF, intraocular pressure, and nerve fiber layer thickness.
Main Methods:
- Langham Pneumotonometer used for POBF measurement.
- Scanning laser polarimetry (GDx) employed for nerve fiber layer assessment.
- Comparison of POBF and GDx parameters across three groups: PEX, PEG, and normal.
Main Results:
- POBF was significantly different between normal eyes and those with PEG (p < 0.003).
- A negative correlation was observed between intraocular pressure and POBF.
- GDx parameters showed correlations with POBF, including negative for 'number' and positive for ellipse modulation.
Conclusions:
- POBF measurement did not differentiate PEX from normal eyes.
- POBF was significantly altered in PEG compared to normals.
- Nerve fiber layer thickness correlated with POBF, suggesting a link between ocular hemodynamics and structural changes.