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The role of cyclooxygenase inhibitors in cancer prevention

William F Anderson1, Asad Umar, Jaye L Viner

  • 1Gastrointestinal & Other Cancers Research Group, National Cancer Institute, Division of Cancer Prevention, EPN, Room 2141, 6130 Executive Boulevard, Bethesda, MD 20892-7317, USA.

Current Pharmaceutical Design
|April 12, 2002
PubMed

Insights

Molecularly targeted cancer prevention strategies are being developed. Nonsteroidal anti-inflammatory drugs (NSAIDs) targeting cyclooxygenase (COX) enzymes show promise for low-toxicity cancer prevention.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Carcinogenesis is a multi-step process involving genetic and epigenetic changes under selection pressure.
  • Understanding cancer development opens avenues for molecularly targeted prevention.
  • Ideal chemopreventive agents require low toxicity, morbidity, and cost.

Purpose of the Study:

  • To explore molecularly targeted cancer prevention strategies.
  • To identify promising classes of chemopreventive agents.

Main Methods:

  • Evaluation of individual agents and combinations in the U.S. National Cancer Institute's program.
  • Focus on agents targeting molecular pathways involved in carcinogenesis.

Main Results:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibiting cyclooxygenase (COX)-1 and -2 are identified as highly promising.
  • These agents represent a key class for targeted molecular prevention.

Conclusions:

  • Targeted molecular prevention is a viable strategy for cancer control.
  • NSAIDs offer a promising therapeutic avenue for cancer chemoprevention due to their COX inhibitory action.

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