Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Organization01:13

Protein Organization

Overview
Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein and Protein Structures02:15

Protein and Protein Structures

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immediate and Mid-Long-Term Effects of Foot Orthoses on Gait Biomechanics and Clinical Characteristics in Medial Knee Osteoarthritis: A Systematic Review and Meta-analysis.

Annals of biomedical engineering·2026
Same author

Advancing Conservative Treatment of Knee Osteoarthritis: 3D-Printed Shoe Soles for Passive Toe-Out Gait Modification.

Journal of foot and ankle research·2026
Same author

Pose-aware deep perceptual similarity for iterative 2D/3D registration of knee joints using contrastive learning.

International journal of computer assisted radiology and surgery·2026
Same author

Passive Laxity in Patients With Subjective Instability Following a Cruciate-Retaining Total Knee Arthroplasty: A Pilot Study.

JB & JS open access·2026
Same author

Enhanced Molecular Staging of Pancreatic Cancer Using Methylated DNA Markers in Peritoneal Lavage Fluid.

Journal of surgical oncology·2026
Same author

Can we identify which patients are likely to have septic arthritis with borderline synovial fluid cell counts?

Journal of bone and joint infection·2026
Same journal

Six ways to put the public at the heart of science and policy.

Nature·2026
Same journal

The complex truth about trust in science.

Nature·2026
Same journal

Have people stopped trusting science? The data tell a surprising story.

Nature·2026
Same journal

How FAIR data are helping to build trust in science.

Nature·2026
Same journal

Scientists should recognize their own political biases to build public trust.

Nature·2026
Same journal

Harmonizing standards and resources for the medical genome.

Nature·2026
See all related articles

Related Experiment Video

Updated: May 11, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

A 'periodic table' for protein structures.

William R Taylor1

  • 1Division of Mathematical Biology, National Institute for Medical Research, London, UK. wtaylor@nimr.mrc.ac.uk

Nature
|April 12, 2002
PubMed
Summary
This summary is machine-generated.

This study introduces a formal method to define protein topology by analyzing secondary and tertiary links. This approach enables rigorous and automated classification of protein structures, overcoming limitations of previous subjective methods.

More Related Videos

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

Related Experiment Videos

Last Updated: May 11, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

Area of Science:

  • Structural biology
  • Bioinformatics
  • Computational biology

Background:

  • Structural genomics aims to catalog all protein structures.
  • Previous estimates of protein structure diversity vary widely due to limited data and subjective classification methods.
  • Distinguishing protein structures topologically is challenging due to the sensitivity of current methods to minor structural changes.

Purpose of the Study:

  • To develop a formal and automated method for defining protein topology.
  • To establish a robust system for classifying protein structures based on their topological features.
  • To overcome the limitations of subjective and non-automatable methods in protein structure comparison.

Main Methods:

  • Formalization of secondary links (hydrogen bonds) and tertiary links (secondary structure packing).
  • Development of algorithms for rigorous and automatic definition of protein topology.
  • Analysis of protein chain topology considering secondary and tertiary structural elements.

Main Results:

  • A novel, formalized approach to defining protein topology has been established.
  • The proposed method allows for rigorous and automatic classification of protein structures.
  • This formalization provides a robust framework for analyzing protein structure diversity.

Conclusions:

  • The formalized method offers a significant advancement in the objective classification of protein structures.
  • This approach is amenable to automation, facilitating large-scale structural genomics efforts.
  • The rigorous definition of protein topology will enhance our understanding of protein structure-function relationships.