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Updated: May 14, 2026

Detection of Infectious Virus from Field-collected Mosquitoes by Vero Cell Culture Assay

Detection of Infectious Virus from Field-collected Mosquitoes by Vero Cell Culture Assay

Published on: June 9, 2011

Recently discovered blood-borne viruses.

I K Mushahwar¹, J E Erker, B J Dille

¹Viral Discovery Group, Abbott Diagnostic Division, Abbott Laboratories, North Chicago, Illinois, USA.

Forum (Genoa, Italy)

|April 12, 2002

Summary

Molecular biology advances have identified two new blood-borne viruses: GB virus C (GBV-C) and TT virus (TTV). While GBV-C infections are typically mild, TTV has not been definitively linked to any disease.

Area of Science:

* Molecular Virology
* Infectious Diseases

Background:

* Advances in molecular biology have facilitated the discovery of viruses previously uncharacterizable by cell culture.
* Two significant blood-borne viruses, GB virus C (GBV-C) and TT virus (TTV), have been identified.

Purpose of the Study:

* To describe the characteristics and prevalence of GBV-C and TTV.
* To review the current understanding of the pathogenicity of these two viruses.

Main Methods:

* Characterization of GBV-C and TTV based on physical properties (particle size, density) and genomic structure (RNA/DNA, size).
* Review of epidemiological data regarding global distribution and clinical outcomes of infections.

Main Results:

* GBV-C: A flavivirus-like enveloped virus with positive-sense RNA genome (~8600 nucleotides), 50-100 nm diameter, density 1.08-1.13 g/cm3. Infections are generally asymptomatic, transient, and self-limiting.

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* TTV: A non-enveloped virus with a circular single-stranded DNA genome (~3900 nucleotides), 30-50 nm diameter, density 1.31-1.34 g/cm3. Global distribution is widespread.

* No definitive association between TTV and disease has been established to date.

Conclusions:

* GBV-C and TTV represent novel viral agents identified through modern molecular techniques.
* GBV-C infections appear to be largely benign, while the clinical significance of TTV remains undetermined.
* Further research is warranted to fully elucidate the long-term health implications of TTV infection.