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Indium-113m perfusion study and the nonfunctioning thyroid nodule.

W J Shih

    Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
    |December 1, 1975
    PubMed
    Summary
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    Indium-113m eluate effectively studied thyroid nodule perfusion in 12 patients. This imaging technique may help differentiate benign colloid nodules from potentially malignant adenomas or carcinomas.

    Area of Science:

    • Nuclear Medicine
    • Oncology
    • Endocrinology

    Background:

    • Solitary thyroid nodules are common, and differentiating benign from malignant types is crucial.
    • Radioiodine (131I) and technetium-99m (99mTc) scintigraphy are standard for evaluating thyroid nodules, often identifying
    • cold
    • nodules with indeterminate significance.

    Purpose of the Study:

    • To evaluate the utility of Indium-113m (¹¹³Inᵐ) eluate perfusion imaging in characterizing solitary thyroid nodules previously classified as
    • cold
    • on conventional scintigraphy.

    Main Methods:

    • A prospective study involving 12 patients with solitary thyroid nodules.
    • All patients underwent perfusion imaging using Indium-113m eluate.

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  • Histological examination was performed for all nodules to confirm diagnoses.

    • Main Results:

    • Seven patients with colloid nodules demonstrated no perfusion on ¹¹³Inᵐ imaging.
    • The remaining five patients, including three with adenomas and two with carcinomas, showed good perfusion with ¹¹³Inᵐ.
    • Histological confirmation supported the imaging findings in all cases.

    Conclusions:

    • Indium-113m perfusion imaging shows promise in differentiating benign colloid nodules from adenomas and carcinomas.
    • This technique may serve as a valuable adjunct to conventional scintigraphy for solitary thyroid nodules.