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Streptococcus pneumoniae bacteremia in southern Taiwan
1Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, ROC.
Summary
Streptococcus pneumoniae infections are increasingly resistant to antibiotics like penicillin. Patients with liver cirrhosis face high mortality and should receive the pneumococcal vaccine.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Public Health
Background:
- Streptococcus pneumoniae bacteremia poses a significant health threat.
- Understanding antimicrobial resistance patterns and serotypes is crucial for effective treatment.
- Taiwan has seen a rise in antibiotic-resistant pneumococcal infections.
Purpose of the Study:
- To analyze antimicrobial susceptibility and serotypes of S. pneumoniae isolates.
- To identify risk factors for mortality in patients with S. pneumoniae bacteremia.
- To assess the relevance of the 23-valent pneumococcal vaccine.
Main Methods:
- Prospective study of 33 patients with S. pneumoniae bacteremia.
- Antimicrobial susceptibility testing was performed.
- Serotyping of clinical isolates was conducted.
Main Results:
- The most common serotypes were 14, 3, and 23F.
- High resistance rates observed for erythromycin (81.9%), tetracycline (69.7%), and clindamycin (69.7%).
- Penicillin non-susceptibility was 42.4%; mortality rate was 42.4%.
- Liver cirrhosis was an independent risk factor for mortality (OR=9.998).
Conclusions:
- All identified S. pneumoniae strains were covered by the 23-valent pneumococcal vaccine.
- Liver cirrhosis patients should be vaccinated against pneumococcal disease.
- Continuous monitoring of S. pneumoniae resistance is essential.