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Haemophilus influenzae type b meningitis with subdural effusion: a case report
1Department of Pediatrics, National Taiwan University Hospital, Taipei, ROC.
Abstract:
Haemophilus influenzae type b causes invasive infection in children under 2 years of age. The disease may be complicated with hearing impairment, lowered learning ability, and other neurologic sequelae. The incidence of invasive H. influenzae type b has declined dramatically after the introduction of routine administration of protein-conjugated H. influenzae type b vaccine in the United States and some other countries. Because of its low incidence in Taiwan, many clinicians are not familiar with the initial symptoms and management of H. influenzae type b. This case report describes a 7-month-old H. influenzae type b meningitis patient who had initial presentations of prolonged intermittent fever and vague neurologic signs. Left peripheral facial palsy with hearing loss in left ear and bilateral frontal subdural effusion developed during the first 5 days of cefotaxime therapy. Betamethasone was then given for 4 days to relieve the severe inflammation. Drug-induced fever was observed after 11 days of antibiotic use and subsided with prednisolone treatment. Left ear hearing impairment persisted during the follow-up period, but the children did not experience other significant development delay.
Insights
Haemophilus influenzae type b meningitis in infants can present with subtle symptoms. Early recognition and management are crucial, though sequelae like hearing loss may persist.
Area of Science:
- Pediatrics
- Infectious Diseases
- Neurology
Background:
- Haemophilus influenzae type b (Hib) causes invasive infections in young children, potentially leading to severe neurologic sequelae.
- Routine Hib vaccination has significantly reduced invasive Hib disease incidence globally.
- Low incidence in Taiwan means clinicians may lack familiarity with Hib meningitis presentation and management.
Observation:
- A 7-month-old infant presented with prolonged fever and vague neurologic signs, diagnosed with Hib meningitis.
- Facial palsy, hearing loss, and subdural effusion developed during initial cefotaxime treatment.
- Betamethasone and prednisolone were used to manage inflammation and drug-induced fever.
Findings:
- The patient experienced persistent left ear hearing impairment post-treatment.
- No significant developmental delay was noted during follow-up.
- Hib meningitis management in low-incidence settings requires careful monitoring for complications.
Implications:
- This case highlights the importance of considering Hib meningitis in infants with non-specific symptoms, even in low-incidence areas.
- Awareness of potential complications like hearing loss and facial palsy is vital for clinicians.
- Prompt and appropriate management, including adjunctive therapies, can mitigate severe outcomes, but long-term sequelae may occur.
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