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Regiocontrolled synthesis of substituted thiazoles
Kevin J Hodgetts1, Mark T Kershaw
1Neurogen Corporation, 35 Northeast Industrial Road, Branford, Connecticut 06405, USA. khodgetts@nrgn.com
Organic Letters
|April 13, 2002
Abstract:
The regiocontrolled synthesis of 2,5-disubstituted and 2,4,5-trisubstituted thiazoles from ethyl 2-bromo-5-chloro-4-thiazolecarboxylate 1 using sequential palladium-catalyzed coupling reactions is described. [reaction: see text]