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Risk factors in miscarriage: a review
A García-Enguídanos1, M E Calle, J Valero
1Department of Human Reproduction, Clínica Tambre, Madrid, Spain. agarcia@clinicatambre.com
Summary
Miscarriage, a frequent pregnancy issue, affects 17-22% of pregnancies. This review discusses recognized causes like uterine malformations and chromosomal issues, alongside other potential risk factors.
Area of Science:
- Reproductive Medicine
- Obstetrics
- Genetics
Background:
- Miscarriage is a common complication in human pregnancy.
- The World Health Organization (WHO) definition from 1977 is widely accepted.
- Incidence rates range from 12-15% for clinical pregnancies to 17-22% including early losses.
Purpose of the Study:
- To review established and potential etiologic factors of miscarriage.
- To discuss recognized causes and other suggested risk factors for pregnancy loss.
Main Methods:
- Literature review of miscarriage etiologies.
- Synthesis of data on recognized and suggested risk factors.
Main Results:
- Uterine malformations and parental chromosomal rearrangements are universally accepted causes.
- Various other potential risk factors have been proposed in the literature.
Conclusions:
- Understanding the diverse causes of miscarriage is crucial for reproductive health.
- Further research into suggested risk factors may improve prevention and management strategies.