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The hyaluronan receptor, CD44.

Clare M Isacke¹, Helen Yarwood

¹The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK. c.isacke@icr.ac.uk

The International Journal of Biochemistry & Cell Biology

|April 16, 2002

Summary

The cell surface receptor CD44 interacts with matrix metalloproteinases (MMPs), influencing cell migration. Understanding this CD44-MMP interplay is crucial for disease pathology research.

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Area of Science:

Cell Biology
Molecular Biology
Biochemistry

Background:

CD44 is a cell surface receptor that binds hyaluronan.
CD44 plays a critical role in cell migration processes.
Dysregulation of CD44 is implicated in various disease pathologies.

Purpose of the Study:

To investigate the molecular mechanisms of cell migration mediated by CD44.
To elucidate the interplay between CD44 and matrix metalloproteinases (MMPs).
To understand the implications of CD44 mis-regulation in disease.

Main Methods:

Review of recent scientific literature.
Analysis of molecular interactions between CD44 and MMPs.
Examination of cellular migration assays.

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Main Results:

Evidence suggests a significant interplay between CD44 and MMPs.
This interaction influences the molecular mechanisms of cell migration.
The CD44-MMP axis is a key factor in cellular motility.

Conclusions:

The interplay between CD44 and MMPs provides critical insights into cell migration.
Understanding this relationship is vital for comprehending CD44's role in disease.
Targeting the CD44-MMP pathway may offer therapeutic strategies for related pathologies.