Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental model of dissecting aneurysms.

Takeshi Okamoto1, Shigeru Miyachi, Makoto Negoro

  • 1Department of Neurosurgery, Nagoya University Graduate School of Medicine, Japan.

AJNR. American Journal of Neuroradiology
|April 16, 2002
PubMed
Summary

The size of the intimal entry zone in arterial dissection significantly influences healing outcomes, potentially leading to aneurysm formation or complete occlusion. This experimental model reveals key morphologic changes following dissection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Room-temperature hyperpolarization <i>via</i> polarization relay through rapid cocrystallization.

Chemical science·2026
Same author

Enhancement of triplet-triplet annihilation upconversion in organically modified clay colloids.

Physical chemistry chemical physics : PCCP·2026
Same author

EXPRESS: Toll Like Receptor 4 (TLR4) in Neuroinflammation: From Acute Hemorrhagic Stroke to Chronic Neurodegeneration.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

The Clinical Impact of Prognostic Nutritional Index at Recurrence of Pancreatic Cancer.

Cancer diagnosis & prognosis·2026
Same author

A diagnostic pitfall of CT calcium scoring in paradoxical low-flow, low-gradient severe aortic stenosis with rheumatic morphology: a case report.

European heart journal. Case reports·2026
Same author

Rare Extrahepatic Metastasis of Hepatocellular Carcinoma to the Left Triangular Ligament: A Case Report.

Surgical case reports·2026

Area of Science:

  • Vascular Surgery
  • Experimental Pathology
  • Medical Imaging

Background:

  • Arterial dissection pathogenesis and optimal treatment remain incompletely understood.
  • An experimental model was developed to investigate arterial dissection.

Purpose of the Study:

  • To observe morphologic changes following experimental arterial dissection using angiography.
  • To correlate intimal entry zone size with dissection outcomes.

Main Methods:

  • Sixty-four experimental arterial dissections were created in canine common carotid arteries.
  • Elliptical or longitudinal intimal defects served as entry zones for dissection.
  • Angiography and pathologic examination were used to assess arterial changes.

Main Results:

Related Experiment Videos

  • Massive subadventitial hematomas and stenosis were observed immediately after dissection.
  • Outcomes varied with entry zone size: complete healing, aneurysm formation, or arterial occlusion.
  • Mature aneurysms showed endothelialization of the dome.

Conclusions:

  • Morphologic changes after arterial dissection are strongly related to the intimal entry zone size.
  • The size of the intimal entry zone may predict the likelihood of dissecting aneurysm formation.