Related Experiment Video
Updated: Aug 12, 2026

Rapid Isolation of BMPR-IB+ Adipose-Derived Stromal Cells for Use in a Calvarial Defect Healing Model
Published on: February 24, 2017
Traumatic cranial defects reconstructed with the HTR-PMI cranioplastic implant
1Department of Neurosurgery, University of Cincinnati Medical Center, Mayfield Clinic and Spine Institute, Cincinnati, Ohio, USA.
Abstract:
Titanium mesh, polymethyl methacrylate application, and autogenous bone grafting have been used to reconstruct traumatic cranial defects, with varying success. A more recent technique utilizing hard tissue replacement-patient matched implants (HTR-PMIs) involves the production of a cranioplastic implant using three-dimensional computed tomography imaging. It has proven less time-consuming and provides an excellent cosmetic result for the patient. The authors present two case reports using this technique to correct traumatic cranial defects. Both patients exhibited satisfactory results and no postoperative complications. The authors believe this relatively new technique represents an advance in the management of large cranial defects.

