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Related Experiment Videos

Mannitol and maintenance hemodialysis.

A P Swamy, R V Cestero

    Artificial Organs
    |May 1, 1979
    PubMed
    Summary

    Mannitol accumulates in patients undergoing maintenance hemodialysis, even with adequate dialyzer clearance. Repeated use of this osmotic agent leads to significant residual levels, requiring further clinical evaluation.

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    Clinical and experimental dialysis and apheresis·1981

    Area of Science:

    • Nephrology
    • Pharmacokinetics
    • Renal Replacement Therapy

    Background:

    • Mannitol is extensively used in maintenance hemodialysis.
    • Understanding mannitol kinetics is crucial due to its widespread application.

    Purpose of the Study:

    • To investigate the kinetics of mannitol during maintenance hemodialysis.
    • To assess mannitol removal efficiency and accumulation in patients.

    Main Methods:

    • Studied 17 patients receiving empirical mannitol therapy.
    • Measured in vitro and in vivo mannitol clearance using CDAK 5, PF 1.6, and Triex 1 dialyzers.

    Main Results:

    • In vitro mannitol clearance exceeded 125 ml/min for CDAK 5 and PF 1.6 dialyzers.
    • In vivo clearance ranged from 98 to 140 ml/min across tested dialyzers.
    • Mannitol was incompletely removed, leading to accumulation with repeated use, with residual levels from 19 to 100 mg%.

    Conclusions:

    • Despite adequate dialyzer clearance rates, mannitol is not completely removed during hemodialysis.
    • Repeated administration of mannitol results in its accumulation in patients.
    • The clinical significance of residual mannitol levels warrants further investigation.

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