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Tungsten-containing enzymes.

N P L'vov1, A N Nosikov, A N Antipov

  • 1Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, 117071 Russia. lvov@mx.inbi.ras.ru

Biochemistry. Biokhimiia
|April 16, 2002
PubMed
Summary
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Tungsten

Area of Science:

  • Biochemistry
  • Enzymology
  • Microbiology

Background:

  • Tungsten's biological role was recently established through the discovery of tungsten-containing enzymes (W-enzymes) in hyperthermophilic archaea.
  • Historically, tungsten was viewed as a molybdenum antagonist due to its interference with molybdenum-containing enzymes (Mo-enzymes).

Purpose of the Study:

  • To review the catalytic roles of tungsten in various enzymes.
  • To summarize the structural characteristics of W-enzyme active sites.

Main Methods:

  • Literature review of recent findings on tungsten-dependent enzymes.
  • Analysis of structural data for W-enzyme active sites.

Main Results:

  • Identification of "true W-enzymes" where tungsten is essential and cannot be substituted by molybdenum.

Related Experiment Videos

  • Discovery of enzymes capable of utilizing either molybdenum or tungsten in catalysis.
  • Characterization of active site structures in W-enzymes.

    • Conclusions:

    • Tungsten plays a crucial catalytic role in a growing number of enzymes, particularly in archaea.
    • The understanding of tungsten's biological significance has expanded beyond its antagonistic role with molybdenum.