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Cytokeratin expression in pilonidal sinus
I Kurokawa1, S Nishijima, K Suzuki
1Department of Dermatology, Hyogo Prefectural Tsukaguchi Hospital, 6-8-17, Minamitsukaguchi-cho, Amagasaki, Hyogo 661-0012, Japan. ikuro@alles.or.jp
The British Journal of Dermatology
|April 16, 2002
Summary
Pilonidal sinus (PS) shares characteristics with follicular occlusion diseases. Cytokeratin (CK) expression analysis suggests PS epithelium is fragile, hyperproliferative, and undifferentiated, supporting its classification within this disease group.
Area of Science:
- Dermatology
- Pathology
- Molecular Biology
Background:
- Pilonidal sinus (PS) is often categorized with follicular occlusion diseases, such as the acne triad.
- Understanding the pathogenesis of PS is crucial for effective treatment strategies.
Purpose of the Study:
- To investigate the pathogenesis of Pilonidal Sinus (PS).
- To evaluate cytokeratin (CK) expression patterns in PS tissue.
- To determine if CK expression can classify PS within follicular occlusion diseases.
Main Methods:
- Immunohistochemical analysis of cytokeratin (CK) expression.
- Utilized six different antikeratin antibodies.
- Examined nine cases of Pilonidal Sinus (PS).
Main Results:
- Infundibular-like epithelium in PS expressed CK1, 10, and 14, but lacked CK17.
- Non-infundibular-like epithelium showed CK14, 16, and 17, similar to normal outer root sheath.
- CK expression in PS resembled that of hidradenitis suppurativa, indicating fragile, hyperproliferative, and undifferentiated sinus epithelium.
Conclusions:
- Cytokeratin (CK) expression patterns support classifying Pilonidal Sinus (PS) within the spectrum of follicular occlusion diseases.
- The findings suggest a shared pathogenic mechanism between PS and other follicular occlusion disorders.
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