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Periungal hyperpigmentation induced by cisplatin.

K J Kim¹, S E Chang, J H Choi

¹Department of Dermatology, Asan Medical Center, College of Medicine, University of Ulsan, 388-1 Poongnap-dong, Songpa-gu, Seoul 138-736, Korea.

Clinical and Experimental Dermatology

|April 16, 2002

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Cisplatin (cis-diamminedichloroplatinum) can cause skin pigment changes. This report details a rare case of hyperpigmentation specifically around the nails after cisplatin treatment.

Area of Science:

Oncology
Dermatology
Pharmacology

Background:

Anticancer agents, including platinum-based drugs, are known to cause cutaneous side effects.
Pigmentary changes, such as hyperpigmentation, are among the documented adverse effects of chemotherapy.
Previous literature has reported limited instances of cisplatin-induced hyperpigmentation.

Observation:

A patient undergoing treatment with cisplatin developed noticeable hyperpigmentation.
The observed pigmentary changes were uniquely localized to the periungal areas of the hands and feet.
This presentation represents an unusual pattern of cisplatin-induced skin toxicity.

Findings:

Cisplatin (cis-diamminedichloroplatinum) can induce localized hyperpigmentation.
The periungal region is a potential site for this specific adverse reaction.

Related Experiment Videos

This case expands the known spectrum of cisplatin-related dermatologic toxicities.

Implications:

Clinicians should be aware of the potential for cisplatin to cause localized periungal hyperpigmentation.
Early recognition of this side effect may aid in patient management and monitoring.
Further research may elucidate the mechanisms behind this specific pigmentary change.