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Procedures for Identifying Infectious Prions After Passage Through the Digestive System of an Avian Species
12:00

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Published on: November 6, 2013

Factor VIII and transmissible spongiform encephalopathy: the case for safety

L Cervenakova1, P Brown, D J Hammond

  • 1J. Holland Laboratory, American Red Cross, Rockville, MD 20855, USA. cervenak@usa.redcross.org

Haemophilia : the Official Journal of the World Federation of Hemophilia
|April 16, 2002
PubMed

Haemophilia A is the most common inherited bleeding disorder, caused by a deficiency in coagulation factor VIII (FVIII). Current treatment of haemophilia A is based on repeated infusions of plasma-derived FVIII concentrate or of recombinant FVIII, which may be exposed to plasma-derived material of human or animal origin used in its tissue culture production process. We review epidemiological and experimental studies relevant to blood infectivity in the transmissible spongiform encephalopathies (TSEs, or 'prion' diseases), and evaluate the hypothetical risk of TSE transmission through treatment with plasma-derived or recombinant FVIII.

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