Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Osteogenic stem-cell characterization and development: potentials for cytotherapy.

J T Triffitt1, R O Oreffo, A S Virdi

  • 1Bone Research Laboratory, Nuffield Department of Orthopaedic Surgery, University of Oxford, Oxford, UK.

Cytotherapy
|April 16, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physiological responses of Robinia pseudoacacia L. of different origins to soil nitrogen supply.

Plant biology (Stuttgart, Germany)·2026
Same author

[Spiradenoma with adenoid cystic carcinoma-like changes: a clinicopathological and genetic molecular analysis of three cases].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2025
Same author

[Risk of and response to cross-border importation and secondary transmission of malaria].

Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control·2025
Same author

Association between non-alcoholic fatty liver disease and metabolic abnormalities in children with different weight statuses.

Public health·2024
Same author

[Collaboration between clinical and public health services: an important guarantee for consolidating malaria elimination achievements].

Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control·2024
Same author

Multiparametric MRI-based radiomics nomogram for predicting malignant transformation of sinonasal inverted papilloma.

Clinical radiology·2023

Postnatal primitive bone progenitors possess stem-cell traits, differentiating into various connective tissues. Cell-fate studies show potential for gene therapy in bone deficiency diseases.

Area of Science:

  • Stem Cell Biology
  • Regenerative Medicine
  • Bone Tissue Engineering

Background:

  • Postnatal primitive bone progenitors exhibit stem-cell characteristics.
  • These cells have extensive renewal potential and can differentiate into multiple connective tissue types.

Purpose of the Study:

  • To characterize osteogenic stem cells and assess their differentiation.
  • To investigate cell-fate and therapeutic potential for bone deficiency diseases.

Main Methods:

  • Utilized various techniques including in vitro/in vivo differentiation assays.
  • Employed antibodies (Abs) to identify surface markers and gene expression analysis.
  • Incorporated marker genes (beta-galactosidase, green fluorescent protein) for cell-fate studies.

Related Experiment Videos

Main Results:

  • Identified antigenic cell-surface molecules reactive with monoclonal antibodies (MAbs).
  • Successfully used retroviral gene insertion for cell-fate tracking in human marrow stromal progenitors.
  • Demonstrated in vivo migration and persistence of marrow stromal cells post-transplantation.

Conclusions:

  • Surface marker antigens appear involved in cell adhesion and signaling, crucial for osteogenic development.
  • Cell-fate studies highlight feasibility for gene therapy in bone deficiency diseases.
  • Potential for developing novel therapeutic strategies for skeletal conditions.