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Updated: Jul 29, 2026
09:01
An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 11, 2013
[Pulmonary function in infants with respiratory syncytial virus bronchiolitis]
Xiaochun Rao1, Xicheng Liu, Qinbo Jiang
1Centre of Bronchoscope, Pediatric Research Institute, Beijing Children's Hospital Affiliated to Capital University of Medical Sciences, Beijing 100045, China.
Zhonghua Yi Xue Za Zhi
|April 16, 2002
Summary
Infants with respiratory syncytial virus (RSV) bronchiolitis experience significant pulmonary function abnormalities, including increased airway resistance. These issues largely resolve within weeks, indicating pulmonary function testing is valuable for monitoring RSV bronchiolitis prognosis.
Area of Science:
- Pediatric Pulmonology
- Infectious Diseases
- Respiratory Physiology
Context:
- Respiratory Syncytial Virus (RSV) bronchiolitis is a common lower respiratory tract infection in infants.
- Pulmonary function abnormalities are suspected during acute RSV bronchiolitis but not well-characterized.
- Understanding these dynamics is crucial for assessing disease severity and prognosis.
Purpose:
- To investigate the temporal changes in pulmonary function during and after acute RSV bronchiolitis in infants.
- To compare pulmonary function parameters in infants with RSV bronchiolitis to healthy controls.
- To identify sensitive pulmonary function indices for monitoring disease course.
Summary:
- Infants with RSV bronchiolitis exhibited significantly increased respiratory resistance and decreased lung volumes during the acute phase compared to controls.
- Pulmonary function gradually improved during recovery, with most parameters normalizing within one week post-discharge.
- Certain indices, like %V-PF, 25/PF, and FRC/kg, remained sensitive indicators of persistent dysfunction.
Impact:
- Pulmonary function testing can effectively monitor the course and predict the prognosis of RSV bronchiolitis.
- Findings highlight the presence of small airway obstruction and ventilatory disturbances in acute RSV bronchiolitis.
- The study identifies specific sensitive markers for assessing recovery and potential long-term effects.
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