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Published on: October 20, 2017
[The clinical features and treatment of cerebral cavernous angiomas in children]
Jian Xie1, Zhenyu Ma, Shiqi Luo
1Department of Neurosurgery, Beijing Tiantan Hospital, Beijing 100050, China.
Insights
Cerebral cavernous angiomas in children often present with epilepsy and neurological deficits. Magnetic resonance imaging (MRI) is key for diagnosis, and surgery offers satisfactory outcomes for pediatric cases.
Area of Science:
- Pediatric Neurology
- Neurosurgery
- Neuroradiology
Background:
- Cerebral cavernous angiomas (CCAs) are vascular malformations that can cause significant neurological symptoms in children.
- Hemorrhage from CCAs is a primary concern, leading to diverse clinical presentations.
Purpose of the Study:
- To outline the clinical characteristics, diagnostic approaches, and treatment strategies for pediatric cerebral cavernous angiomas.
- To evaluate the efficacy of surgical intervention for these lesions in children.
Main Methods:
- Retrospective analysis of clinical data from 30 pediatric patients with CCAs over 11 years.
- Review of diagnostic imaging, primarily Magnetic Resonance Imaging (MRI), and surgical outcomes.
Main Results:
- Epilepsy and focal neurological deficits were the most frequent symptoms, often resulting from recurrent hemorrhages.
- MRI revealed characteristic high or complex abnormal signals, with a distinctive ring-shaped low signal around lesions on T2-weighted images.
- Surgical treatment yielded satisfactory results for the majority of patients.
Conclusions:
- Magnetic Resonance Imaging (MRI) is the optimal modality for diagnosing and monitoring cerebral cavernous angiomas in pediatric patients.
- Surgical intervention is the preferred treatment option for pediatric cerebral cavernous angiomas, offering positive outcomes.
Objective:
To discuss the clinical features, diagnosis and treatment of cerebral cavernous angiomas in children.
Methods:
The clinical data of 30 cases of cavernous angioma hospitalized in the past 11 years, 25 boys and 5 girl, with an average age of 9.4 years, of which 27 underwent operation, were analyzed retrospectively.
Results:
Epilepsy and focal neurological deficits caused by repeated hemorrhage of lesion were the most common symptoms. MRI appearances were mainly high or complex abnormal signal. Ring-shaped low signal could be seen around the lesions by T1 and T2, especially by T2. The results of operation were satisfactory.
Conclusion:
MRI examination is the best method for diagnosis and follow-up of cerebral cavernomas. Operation is the first choice for paediatric cavernous angioma.
