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Related Experiment Videos

Modulation of mouse endotoxic fever by complement.

S Li1, V M Holers, S A Boackle

  • 1Department of Physiology, The University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.

Infection and Immunity
|April 16, 2002
PubMed
Summary
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The complement system

Area of Science:

  • Immunology
  • Physiology
  • Microbiology

Background:

  • The complement system's role in fever response to lipopolysaccharides (LPS) was previously suggested.
  • Lipopolysaccharides (LPS) are key components of Gram-negative bacteria.

Purpose of the Study:

  • To identify specific complement cascade components critical for LPS-induced fever.
  • To investigate the role of C3, C5, and CR2 in the febrile response.

Main Methods:

  • Utilized gene-deleted mice (C3-/-, C5-/-, CR2-/-) and wild-type controls.
  • Administered intraperitoneal (i.p.) LPS and intravenous (i.v.) cobra venom factor (CVF) for complement depletion.
  • Monitored core body temperature (Tc) changes in response to LPS.

Main Results:

Related Experiment Videos

  • Complement depletion with CVF prevented LPS-induced fever in wild-type mice.
  • C3- and C5-deficient mice did not develop fever after LPS injection.
  • Mice lacking CR2 showed normal fever responses to LPS.

Conclusions:

  • Complement component C5 plays a critical role in the mouse febrile response to i.p. LPS.
  • C3d acting through CR2 is not essential for this LPS-induced fever response.