Related Experiment Video
Updated: Oct 1, 2026

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells
Published on: January 12, 2020
Nuclear factor kappa B signaling in catabolic disorders
1College of Human Ecology and Medicine, Department of Human Nutrition, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210-1295, USA. holmes-mcnary.1@osu.edu
Abstract:
The nuclear factor kappa B family of inducible transcription factors regulates the expression of many genes. Nuclear factor kappa B has been implicated in autoimmune and inflammatory diseases, infection, cell survival, and cell transformation with subsequent promotion of cancer. In this review, we summarize features of nuclear factor kappa B regulation in several catabolic disorders, and describe its role in normal cellular function as well as provide an important link to the role of scaffold proteins, cellular receptors, and other cell signaling pathway kinases that converge on the nuclear factor kappa B signaling cascade. Subsequently, we focus on the role of nuclear factor kappa B in cell survival and oxidative stress. Finally, potential therapeutic strategies are discussed that may modify nuclear factor kappa B activity including endogenous antioxidant systems and the Fas/FasL system. However, challenges still remain in developing new therapeutic strategies that not only include identifying novel agents, but also by improving clinical endpoint definitions and by defining biological efficacy.
Related Concept Videos
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
The JAK-STAT Signaling Pathway
Regulation of Nuclear Protein Sorting
Overview of Protein Metabolism
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Co-activators and Co-repressors
Regulation of Metabolism
